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Adverse Effects

Glossy fatigue: week 3 report (blood work included)

DeltaSigma  ·  Sep 2024  ·  2 replies

Three weeks in. No dramatic adverse event. What I have is what I'm calling glossy fatigue — not sleepiness, not cognitive impairment, but a subtle polished quality to my reactions, as if there's a thin coat of something between me and ordinary sensory experience.

I've seen this term used before in the forum without much precision. I'm trying to pin it down more carefully because subjective reports without biomarkers are nearly useless for anyone trying to understand whether this is a real physiological effect or a framing artifact.

Bloodwork from this week: ferritin 84 ng/mL (normal for me), cortisol AM 18.2 µg/dL (slightly elevated — my baseline is usually 14–16), HRV RMSSD average over the past week 31 ms (my pre-protocol baseline was 44 ms). The cortisol elevation and HRV suppression are the most notable findings.

These are consistent with mild, sustained stress — the kind that doesn't feel acutely distressing but shows up in recovery metrics. Whether the cause is the device, anticipatory monitoring, disrupted sleep architecture, or something else entirely, I can't say from this data alone.

If anyone has matched ferritin, cortisol, or HRV changes across the first month of protocol use, I'd like to compare. I'll post follow-up numbers at weeks 6 and 12 regardless.

I tracked HRV for my entire ninety-day run. RMSSD dropped from baseline 48 ms to a trough of 28 ms around week three, then partially recovered to 36 ms by week eight. Never returned to my pre-protocol baseline during the run. After discontinuation, it recovered to 46 ms over about ten days.

I didn't get cortisol data but the HRV pattern is consistent with what you're seeing. I'd categorize it as real and physiological, not a framing artifact.

The glossy fatigue description is accurate for what I experienced around the same period. I described it to a friend as 'having subtitles turned on for reality' — everything slightly annotated rather than experienced directly. Resolved within a week of taking a pause.

I think it's partly sleep architecture disruption and partly the sustained monitoring posture — lying in bed waiting for something to happen every night changes how you relate to the state of sleep itself.

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